Clusters of a virus known to cause stomach flu are resistant to detergent and ultraviolet disinfection, according to new research co-led by Danmeng Shuai, an associate professor of civil and environmental engineering at the George Washington University and Nihal Altan-Bonnet, a senior investigator and the head of the Laboratory of Host-Pathogen Dynamics at the National Heart, Lung and Blood Institute, part of the National Institutes of Health (NIH).
The findings suggest the need to revisit current disinfection, sanitation and hygiene practices aimed at protecting people from noroviruses, the leading cause of gastroenteritis around the world, with more than 21 million cases each year in the United States alone.
The study was published Thursday in the journal Environmental Science and Technology.
In 2018, Altan-Bonnet’s team found that noroviruses can be transmitted to humans via membrane-enclosed packets that contain more than one virus. Scientists previously thought viruses spread through exposure to individual virus particles, but the 2018 study—and others—showed how membrane-enclosed clusters arrive at a human cell and release an army of viruses all at once.
For the new study, Dr. Shuai, Dr. Altan-Bonnet and the study’s first author, Mengyang Zhang, a doctoral student co-advised through a GW/NIH Graduate Partnerships Program, looked at the behavior of these protected virus clusters in the environment. They found that the virus clusters could survive attempts to disinfect with detergent solutions or even ultraviolet light. Water treatment plants use ultraviolet light to kill noroviruses and other pathogens.
“These membrane-cloaked viruses are tricky,” Dr. Shuai said. “Past research shows they can evade the body’s immune system and that they are highly infectious. Our study shows these membrane enclosed viruses are also able to dodge efforts to kill them with standard disinfectants.”
According to the researchers, future studies must be done to find out whether certain kinds of cleaning solutions or higher dosages of ultraviolet light would degrade the protective membrane and/or kill the viruses inside. Ultimately, the research could be used to devise more effective disinfection methods that could be used to clean surfaces at home, in restaurants and in places where norovirus can spread and cause outbreaks, like cruise ships.
“We have to consider these viral clusters cloaked in vesicle membranes as unique infectious agents in the public health arena,” Dr. Altan-Bonnet said. “When it comes to virulence—and now with this study, disinfection and sanitation—the sum is much more than its parts. And these clusters are endowed with properties that are absent from other types of viral particles.”
The findings represent a step toward recommendations for pathogen control in the environment, and public health protection, Dr. Altan-Bonnet said.
This work was supported by the National Science Foundation, the National Heart, Lung and Blood Institute, and National Institute of Allergy and Infectious Diseases Intramural Research Programs.
